RM-IMM / Immune and host-defense signaling
Thymogen
Also known as: Timogen · Thymagen · EW peptide · L-Glu-L-Trp
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Thymogen is L-Glu-L-Trp. Chirality is identity-critical because the D-Glu-D-Trp peptide discussed as Thymodepressin is a different compound with different reported activity.
Evidence position
Older human intervention reports support Grade B under the site’s grading definition. Their narrow settings, age, language and combination-treatment context sharply limit interpretation.
What the record does not establish
The published records do not establish U.S. approval, broad effectiveness, equivalence across formulations or the quality of any supplier material.
Sources
- 01Thymogen compound recordPubChem
- Shows
- Registry identity and formula for the Glu-Trp dipeptide
- Does not show
- Registry identity does not establish activity, approval or lot quality
- 02Clinical-epidemiological study of Thymogen in acute respiratory infectionsPubMed
- Shows
- Older human intervention record for intranasal and subcutaneous Thymogen
- Does not show
- Russian-language report with limited accessible methods and a narrow setting
- 03Controlled clinical study of Thymogen in chronic bronchitisPubMed
- Shows
- Small controlled human study in a combination-treatment context
- Does not show
- Adjunctive regimen, small sample and older publication stream
- 04Chirality and activity of Thymogen and ThymodepressinPubMed
- Shows
- Modern review defining Thymogen as L-Glu-L-Trp and distinguishing its D-enantiomer counterpart
- Does not show
- Review-level identity and mechanism context, not an independent outcome trial
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Thymogen
- CID
- 100094
- Formula
- C16H19N3O5
- Mass
- 333.34
PUBMED / FOUND RECORDS
- The First Reciprocal Activities of Chiral Peptide Pharmaceuticals: Thymogen and Thymodepressin, as Examples.International journal of molecular sciences / 2024 May 6PMID 38732260 / DOI 10.3390/ijms25095042
- Reparative and Antioxidant Effects of New Analogues of Immunomodulator Thymogen in Experimental Model of Liver Damage.Bulletin of experimental biology and medicine / 2023 SepPMID 37861903 / DOI 10.1007/s10517-023-05929-5
- Immunomodulatory synthetic dipeptide L-Glu-L-Trp slows down aging and inhibits spontaneous carcinogenesis in rats.Biogerontology / 2000PMID 11707921 / DOI 10.1023/a:1010042008969
- Effects of the dipeptide L-glutamic acid-L-tryptophan on dermatitis in mice and human keratinocytes.Heliyon / 2022 JanPMID 35036609 / DOI 10.1016/j.heliyon.2022.e08729
- Hepatoprotective Effects of Thymogen Analogues in Hydrazine Hepatopathy in Rats.Bulletin of experimental biology and medicine / 2025 AprPMID 40442470 / DOI 10.1007/s10517-025-06405-y