RM-IMM / Immune and host-defense signaling
Thymopentin
Also known as: TP-5 · Timunox · RKDVY
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Thymopentin is the defined pentapeptide Arg-Lys-Asp-Val-Tyr. TP-5 and Timunox appear in historical clinical literature.
Evidence position
Controlled human studies support Grade B, but they are older, indication-specific and not a modern approval or manufacturing record.
What the record does not establish
Historical trials do not authenticate current research material or establish broad effects outside the studied populations and protocols.
Sources
- 01Thymopentin therapy in atopic dermatitisPubMed
- Shows
- Randomized placebo-controlled trial in 100 participants
- Does not show
- Older study in one condition; does not establish current approval or product equivalence
- 02Thymopentin in AZT-treated asymptomatic HIV infectionPubMed
- Shows
- Large double-blind placebo-controlled human study with stratum-dependent findings
- Does not show
- Historical treatment context and protocol; not a general immune-effect claim
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Thymopentin
- CID
- 451417
- Formula
- C30H49N9O9
- Mass
- 679.8
PUBMED / FOUND RECORDS
- Copper-coordination driven brain-targeting nanoassembly for efficient glioblastoma multiforme immunotherapy by cuproptosis-mediated tumor immune microenvironment reprogramming.Journal of nanobiotechnology / 2024 Dec 28PMID 39731102 / DOI 10.1186/s12951-024-03059-2
- Thymopentin: safety overview.Survey of immunologic research / 1985PMID 3898287 / DOI 10.1007/BF02919070
- Thymopentin in dermatology.Current problems in dermatology / 1989PMID 2663371 / DOI 10.1159/000416866
- Self-assembly driven nano-salinomycin for high-efficiency cancer immunotherapy by reticulum stress mediated stemness suppression.Biomaterials / 2026 FebPMID 40829508 / DOI 10.1016/j.biomaterials.2025.123632
- Thymopoietin to thymopentin: experimental studies.Survey of immunologic research / 1985PMID 2994196 / DOI 10.1007/BF02919050
CLINICALTRIALS.GOV / FOUND RECORDS
- Double Blind Study of Thymopentin Effects on Patients With HIV-1 InfectionCOMPLETED / NA / Immunobiology Research InstituteNCT00002051 / DIRECT intervention MATCH: Thymopentin
- A Study of Timunox (Thymopentin) in HIV-Infected Patients Receiving Other Anti-HIV DrugsCOMPLETED / PHASE2 / Immunobiology Research InstituteNCT00002332 / DIRECT intervention MATCH: Thymopentin
- Study of Thymopentin in Patients After Curative Resection of Small Hepatocellular CarcinomaUNKNOWN / PHASE3 / Fudan UniversityNCT00460681 / DIRECT intervention MATCH: Thymopentin
- Double-Blind Study of Timunox (Thymopentin) in Asymptomatic HIV-Infected Patients Receiving Either Mono (AZT or ddI) or Combination (AZT / ddI or AZT / ddC) Anti-Retroviral TherapyCOMPLETED / PHASE3 / Immunobiology Research InstituteNCT00002109 / DIRECT intervention MATCH: Thymopentin
- The Effects of Thymopentin on HIV Infectivity of Blood Cells and Semen in HIV-Infected PatientsCOMPLETED / NA / Immunobiology Research InstituteNCT00002289 / DIRECT intervention MATCH: Thymopentin