RM-IMM / Immune and host-defense signaling
LL-37
Also known as: Human cathelicidin LL-37 · Cathelicidin antimicrobial peptide
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
LL-37 is the only human cathelicidin-derived peptide and is produced from the hCAP18 precursor. Its activities vary strongly with concentration, matrix, formulation and experimental model.
Evidence position
Specific human interventional studies support Grade B. The record is not a general validation of LL-37 for unrelated routes, conditions or preparations.
What the record does not establish
Published work does not establish the identity, purity, quantity, sterility or suitability of a commercially supplied lot.
Sources
- 01Evaluation of LL-37 in hard-to-heal venous leg ulcersPubMed
- Shows
- Phase IIb randomized topical trial; no significant difference in the full study cohort
- Does not show
- A specific topical formulation and indication; not injectable or supplier-lot evidence
- 02The roles of cathelicidin LL-37 in immune defencesPubMed
- Shows
- Review of host-defense mechanisms and research directions
- Does not show
- Mechanistic review, not a product-quality or efficacy record
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBMED / FOUND RECORDS
- LL-37: Cathelicidin-related antimicrobial peptide with pleiotropic activity.Pharmacological reports : PR / 2016 AugPMID 27117377 / DOI 10.1016/j.pharep.2016.03.015
- Human cathelicidin (LL-37), a multifunctional peptide, is expressed by ocular surface epithelia and has potent antibacterial and antiviral activity.Current eye research / 2005 MayPMID 16020269 / DOI 10.1080/02713680590934111
- Neutrophil extracellular traps may contribute to interstitial lung disease associated with anti-MDA5 autoantibody positive dermatomyositis.Clinical rheumatology / 2018 JanPMID 28842784 / DOI 10.1007/s10067-017-3799-y
- Functional roles of purified yapsins from Candida glabrata (Nakaseomyces glabratus) in immune modulation and cross-species biofilm formation.Scientific reports / 2025 Sep 1PMID 40890180 / DOI 10.1038/s41598-025-15577-6
- Acne inversa: evaluating antimicrobial peptides and proteins.Annals of dermatology / 2012 NovPMID 23197903 / DOI 10.5021/ad.2012.24.4.393
CLINICALTRIALS.GOV / FOUND RECORDS
- Cathelicidin LL-37 Relation to Potentially Malignant LesionsCOMPLETED / NO PHASE / Fayoum UniversityNCT06219330 / DIRECT title MATCH: LL-37
- Peri-implant Vitamin D and Cathelicidin (LL-37) LevelsCOMPLETED / NO PHASE / Altinbas UniversityNCT06867250 / DIRECT intervention MATCH: LL-37
- Evaluation of the Inhibitory Effects of Topical Ivermectin on Markers of Rosacea Specific Inflammation.COMPLETED / PHASE1, PHASE2 / University of California, San DiegoNCT02806414 / DIRECT title MATCH: LL-37 cathelicidin
- Vitamin D in Active Tuberculosis (TB) StudyWITHDRAWN / NA / Atlanta VA Medical CenterNCT00788320 / DIRECT title MATCH: LL-37 cathelicidin
- Effects of Aminocaproic Acid (ACA) on Rosacea-specific InflammationCOMPLETED / EARLY_PHASE1 / University of California, San DiegoNCT01398280 / DIRECT title MATCH: LL-37 cathelicidin