RM-END / Endocrine and peptide-hormone analogs
Human Secretin
Also known as: Secretin human · ChiRhoStim · Secretin-27
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Human secretin is a 27-amino-acid peptide hormone. The labeled comparator is a purified synthetic, sterile, lyophilized diagnostic presentation.
Evidence position
The regulated diagnostic product and human evidence support Grade A for the exact finished presentation.
What the record does not establish
The label does not authenticate another secretin sample or transfer manufacturing, sterility and potency controls.
Sources
- 01ChiRhoStim prescribing informationDailyMed / U.S. National Library of Medicine
- Shows
- Current U.S. label, peptide-hormone identity and diagnostic injection presentation
- Does not show
- Does not qualify another sequence, source, strength or formulation
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBMED / FOUND RECORDS
- Secretin: historical perspective and current status.Pancreas / 2014 MarPMID 24518494 / DOI 10.1097/01.mpa.0000437325.29728.d6
- Human secretin. Biologic effects and plasma kinetics in humans.Gastroenterology / 1988 FebPMID 2446946
- Structure of the human secretin receptor coupled to an engineered heterotrimeric G protein.Biochemical and biophysical research communications / 2020 Dec 17PMID 33008599 / DOI 10.1016/j.bbrc.2020.08.042
- Structure-activity relationships of thiadiazole agonists of the human secretin receptor.SLAS discovery : advancing life sciences R & D / 2024 SepPMID 39122117 / DOI 10.1016/j.slasd.2024.100176
- Molecular cloning and expression of a human secretin receptor.Molecular pharmacology / 1995 MarPMID 7700244
CLINICALTRIALS.GOV / FOUND RECORDS
- Synthetic Human Secretin in Children With AutismCOMPLETED / PHASE3 / Repligen CorporationNCT00036244 / DIRECT intervention MATCH: Human Secretin
- Synthetic Human Secretin in Children With Autism and Gastrointestinal DysfunctionTERMINATED / PHASE3 / Repligen CorporationNCT00036231 / DIRECT intervention MATCH: Human Secretin
- Secretin-enhanced Magnetic Resonance Cholangiopancreatography (S-MRCP) and Pancreatic Function Following SurgeryWITHDRAWN / NA / Columbia UniversityNCT01094535 / DIRECT intervention MATCH: Human Secretin
- Secretin Enhanced Multidetector CT Pancreatography for Evaluation of Known or Suspected Chronic PancreatitisTERMINATED / PHASE1 / Massachusetts General HospitalNCT00620919 / DIRECT intervention MATCH: Human Secretin
- Safety and Efficacy of Synthetic Human Secretin-Enhanced MRCP in Subjects With Abnormalities of the PancreasCOMPLETED / PHASE3 / Repligen CorporationNCT00660335 / DIRECT intervention MATCH: Human Secretin