RM-END / Endocrine and peptide-hormone analogs
Cosyntropin
Also known as: Cortrosyn · Tetracosactide · ACTH 1-24 · Tetracosactrin
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Cosyntropin is the synthetic 1-24 fragment of adrenocorticotropic hormone. The library keeps the fragment, full hormone and branded diagnostic presentation distinct.
Evidence position
The regulated diagnostic injection and human evidence support Grade A for the labeled product.
What the record does not establish
That label does not authenticate another ACTH fragment or establish an unlabeled sample’s identity, potency or sterility.
Sources
- 01Cosyntropin compound recordPubChem
- Shows
- Registry identity, structure, formula and synonyms for cosyntropin
- Does not show
- Does not establish a diagnostic formulation, strength or lot quality
- 02Cortrosyn prescribing informationDailyMed / U.S. National Library of Medicine
- Shows
- U.S. label for a defined lyophilized cosyntropin diagnostic injection
- Does not show
- Does not qualify another peptide fragment, concentration, route or source
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Cosyntropin
- CID
- 16129617
- Formula
- C136H210N40O31S
- Mass
- 2933.4
PUBMED / FOUND RECORDS
- Safety and effectiveness of hormonal treatment versus hormonal treatment with vigabatrin for infantile spasms (ICISS): a randomised, multicentre, open-label trial.The Lancet. Neurology / 2017 JanPMID 27838190 / DOI 10.1016/S1474-4422(16)30294-0
- Adrenal venous sampling: cosyntropin stimulation or not?European journal of endocrinology / 2019 SepPMID 31176302 / DOI 10.1530/EJE-18-0844
- Atypical hypocortisolism.Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists / 2013 Sep-OctPMID 23757611 / DOI 10.4158/EP12415.CR
- Diagnosis of adrenal insufficiency.Annals of internal medicine / 2003 Aug 5PMID 12899587 / DOI 10.7326/0003-4819-139-3-200308050-00009
- Treatment of infantile spasms.The Cochrane database of systematic reviews / 2013 Jun 5PMID 23740534 / DOI 10.1002/14651858.CD001770.pub3
CLINICALTRIALS.GOV / FOUND RECORDS
- Salivary Free Cortisol Response to Cosyntropin Stimulation Test in Mitotane Treated PatientsUNKNOWN / NA / Bnai Zion Medical CenterNCT03083834 / DIRECT intervention MATCH: Cosyntropin
- Hormonal Mechanisms of Sleep Restriction - Axis Study in Older Men and Postmenopausal WomenACTIVE_NOT_RECRUITING / EARLY_PHASE1 / Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical CenterNCT04037605 / DIRECT intervention MATCH: Cosyntropin
- NeSST2: The Development of a Noninvasive Short Synacthen TestRECRUITING / PHASE2 / Sheffield Children's NHS Foundation TrustNCT03514589 / DIRECT intervention MATCH: Cosyntropin
- Stress and the Nervous SystemCOMPLETED / NA / Brigham and Women's HospitalNCT02339506 / DIRECT intervention MATCH: Cosyntropin
- Adrenocorticotropic Hormone Stimulation in Postural Orthostatic Tachycardia Syndrome (POTS)COMPLETED / NA / Vanderbilt UniversityNCT01764711 / DIRECT intervention MATCH: Cosyntropin