Thyrotropin-releasing hormone

Also known as: TRH · Thyroliberin · Protirelin

Human evidence

Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.

What this is

TRH is a three-residue amidated peptide produced from a larger precursor. It is distinct from longer TRH-associated peptides and synthetic analogs.

Evidence position

Direct human administration and endocrine-response measurements support Grade B.

What the record does not establish

Historical mechanistic studies do not establish current product approval, a safe research workflow, or the identity, concentration and microbiological quality of another sample.

Sources

01
Repetitive TRH administration in human subjectsPubMed
Shows
Direct human endocrine-response data after repeated defined TRH administration
Does not show
Small mechanistic study; does not establish a modern finished product, long-term outcome or supplier lot

External database index

LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE

Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.

PUBMED / FOUND RECORDS

Thyrotropin-releasing hormone.Journal of neurochemistry / 1995 SepPMID 7643125 / DOI 10.1046/j.1471-4159.1995.65030953.x
Thyrotropin-releasing hormone.The New England journal of medicine / 1982 Jan 21PMID 6798440 / DOI 10.1056/NEJM198201213060305
[Thyrotropin releasing hormone].Harefuah / 1982PMID 6820788
Thyrotropin-releasing hormone.Advances in internal medicine / 1974PMID 4205606
[Thyrotropin-releasing hormone (TRH)].Nihon rinsho. Japanese journal of clinical medicine / 2005 AugPMID 16149495

CLINICALTRIALS.GOV / FOUND RECORDS

Study of Antenatal Thyrotropin-Releasing Hormone in Women in Premature Labor to Prevent Lung Disease in Preterm InfantsCOMPLETED / NA / Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)NCT00004840 / DIRECT intervention MATCH: Thyrotropin-releasing hormone
Pharmacogenomic Response to Thyrotropin-Releasing Hormone Stimulation in Healthy Volunteers: The Influence of a Common Type 2 Deiodinase Genetic Polymorphism on Serum T3COMPLETED / NO PHASE / National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NCT00812149 / DIRECT title MATCH: Thyrotropin-releasing hormone
Study of Resistance to Thyroid Hormone After Long-term Exposure in People With Thyroid CancerWITHDRAWN / PHASE1 / Memorial Sloan Kettering Cancer CenterNCT04868045 / DIRECT intervention MATCH: Thyrotropin-releasing hormone
Mechanistic Study of Subclinical Hypothyroidism In the ElderlyCOMPLETED / NA / University of PennsylvaniaNCT02399475 / DIRECT intervention MATCH: Thyrotropin-releasing hormone
Phase III Randomized, Double-Blind, Placebo-Controlled Study of Antenatal Thyrotropin-Releasing Hormone in Pregnant Women With Threatened Premature DeliveryCOMPLETED / PHASE3 / National Center for Research Resources (NCRR)NCT00004778 / DIRECT intervention MATCH: Thyrotropin-releasing hormone

Related compounds

RM-END