RM-TRS / Tissue, repair and matrix signalling
PEG-MGF
Also known as: PEGylated mechano growth factor · PEGylated MGF-E peptide
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
PEG-MGF is not a synonym for full-length IGF-1Ec, the isolated MGF E-domain peptide, or a generic stabilized MGF peptide. A complete identity needs the peptide sequence, PEG molecular weight, attachment site, linkage chemistry and molecular mass.
Evidence position
The current literature search found related MGF research but no direct intervention record for a fully defined PEG-MGF material. That makes this a Grade D related-compound record.
What the record does not establish
Adding PEG can change circulation time, distribution, receptor exposure and analytical behavior. Evidence for an unmodified parent cannot be represented as evidence for the PEGylated analog.
Sources
- 01No apparent effect of MGF peptide on myoblasts or muscle stem cellsPubMed
- Shows
- Independent experiments on native and stabilized isolated MGF-related peptides
- Does not show
- Does not test a chemically defined PEG-MGF material
- 02Full-length MGF and isolated MGF peptide receptor-activation studyPubMed
- Shows
- Different activity between full-length MGF and isolated MGF peptides
- Does not show
- No PEGylated MGF intervention was tested
- 03Performance-enhancing peptides of the GH-IGF-1 axisPubMed
- Shows
- Independent review identifying PEG-MGF as a marketed GH-IGF-axis analog
- Does not show
- Review-level context; not direct evidence for a defined PEG-MGF product
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBMED / FOUND RECORDS
- The emerging landscape of performance-enhancing peptides modulating GH-IGF1 axis: bridging the gap between clinical evidence and patient self-administration.Frontiers in endocrinology / 2026PMID 42395176 / DOI 10.3389/fendo.2026.1822475