RM-GHA / Growth-hormone-axis signalling
IGF-1 LR3
Also known as: Long R3 IGF-1 · LR3 IGF-1
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
IGF-1 LR3 is not native IGF-1. The added N-terminal sequence and Arg3 substitution alter its interaction with IGF-binding proteins and make it a distinct research material.
Evidence position
Direct experiments exist in cell, livestock and rodent models. Grade C reflects that preclinical record and the absence of qualifying human intervention evidence for the exact analog.
What the record does not establish
Native IGF-1 studies, an IGF-1 drug label, or a paper using LR3 as a laboratory reagent do not establish safety, effectiveness, identity or purity for a commercial LR3 vial.
Sources
- 01Action of long(R3)-insulin-like growth factor-1 on protein metabolism in beef heifersPubMed
- Shows
- Direct animal metabolic research using Long R3 IGF-1
- Does not show
- Livestock physiology; not a human intervention or supplier-quality test
- 02IGF-1 has plaque-stabilizing effects in atherosclerosisPubMed
- Shows
- Direct Long R3 IGF-1 experiments in cells and a mouse model
- Does not show
- Preclinical model; does not establish clinical outcomes or product identity
- 03Fetal sheep cardiomyocyte signaling studyPubMed
- Shows
- Direct LR3 IGF-1 receptor-signaling and developmental-heart experiments
- Does not show
- Cell and fetal-sheep research only
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBMED / FOUND RECORDS
- Recombinant expression of IGF-1 and LR3 IGF-1 fused with xylanase in Pichia pastoris.Applied microbiology and biotechnology / 2023 JulPMID 37261455 / DOI 10.1007/s00253-023-12606-0
- IGF-1 LR3 does not promote growth in late-gestation growth-restricted fetal sheep.American journal of physiology. Endocrinology and metabolism / 2025 Jan 1PMID 39679943 / DOI 10.1152/ajpendo.00259.2024
- Attenuated glucose-stimulated insulin secretion during an acute IGF-1 LR3 infusion into fetal sheep does not persist in isolated islets.Journal of developmental origins of health and disease / 2023 JunPMID 37114757 / DOI 10.1017/S2040174423000090
- Revolutionary decellularized Alstroemeria stem-based nerve conduit integrated with GelMA and controlled IGF-1 LR3 release for enhanced rat sciatic nerve regeneration.International journal of biological macromolecules / 2025 NovPMID 41015370 / DOI 10.1016/j.ijbiomac.2025.147888
- Coronary vascular growth matches IGF-1-stimulated cardiac growth in fetal sheep.FASEB journal : official publication of the Federation of American Societies for Experimental Biology / 2020 AugPMID 32573852 / DOI 10.1096/fj.202000215R