RM-TRS / Tissue, repair and matrix signalling
Mechano Growth Factor E peptide
Also known as: MGF · MGF-E · IGF-1Ec E-domain peptide · Mechano growth factor peptide
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
“MGF” can refer to a full IGF-1 splice product, the isolated E-domain peptide, or a stabilized analog such as PEG-MGF. A valid record has to state which material was tested.
Evidence position
The isolated peptide has a mixed preclinical record, including failed replication of commonly cited cell effects. Grade C reflects direct laboratory evidence without human intervention data.
What the record does not establish
Evidence for full-length IGF-1Ec cannot be silently transferred to a 24-residue fragment, a PEGylated analog or a commercial vial.
Sources
- 01No apparent effect of MGF peptide on myoblasts or muscle stem cellsPubMed
- Shows
- Independent in-vitro experiments failed to reproduce several claimed effects of native and stabilized MGF peptides
- Does not show
- Cell models do not resolve every possible in-vivo context or formulation
- 02Full-length MGF and isolated MGF peptide receptor-activation studyPubMed
- Shows
- Full-length MGF activated IGF-1 receptor at high concentrations while isolated MGF peptides did not in the reported assay
- Does not show
- In-vitro receptor assay; does not establish clinical activity or a supplier lot
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBMED / FOUND RECORDS
- Nutrition and growth in children.Minerva pediatrica / 2020 DecPMID 32731734 / DOI 10.23736/S0026-4946.20.05981-2
- The role of hormones in muscle hypertrophy.The Physician and sportsmedicine / 2018 FebPMID 29172848 / DOI 10.1080/00913847.2018.1406778
- Mecasermin.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy / 2008PMID 18481900 / DOI 10.2165/00063030-200822030-00004
- Preface.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society / 2018 FebPMID 29311008 / DOI 10.1016/j.ghir.2017.12.015
- Acromegaly.Nature reviews. Disease primers / 2019 Mar 21PMID 30899021 / DOI 10.1038/s41572-019-0076-1