RM-TRS / Tissue, repair and matrix signalling
Follistatin-344
Also known as: FS344 · FST344 · Follistatin precursor isoform 344
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Follistatin-344 is a large protein precursor isoform, not a conventional short peptide. The mature secreted forms and recombinant constructs can differ in processing, tags, aggregation and biological behavior.
Evidence position
The human FS344 record is gene delivery. Treating it as evidence for an injected recombinant vial would collapse two different interventions, so the entry remains Grade D.
What the record does not establish
A label reading “FS344” does not establish that the vial contains the expected protein. Intact mass, sequence coverage, tag status, aggregation and bioactivity require matched analytical records.
Sources
- 01Phase 1/2a FS344 gene-therapy trialPubMed
- Shows
- Human study of AAV-mediated expression of the FS344 isoform
- Does not show
- Gene transfer is not an injectable follistatin-344 protein and cannot validate retail material
- 02Detection of black-market follistatin 344PubMed
- Shows
- Analytical study found follistatin in 9 of 17 tested products and other growth-promoting peptides in some samples
- Does not show
- Applies to the examined samples; does not approve or condemn every supplier lot
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBMED / FOUND RECORDS
- Exercise in Myositis.Current treatment options in rheumatology / 2018PMID 30613464 / DOI 10.1007/s40674-018-0113-3
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.Sports medicine (Auckland, N.Z.) / 2026 Apr 12PMID 41966639 / DOI 10.1007/s40279-026-02437-0
- Detection of black market follistatin 344.Drug testing and analysis / 2019 NovPMID 31758732 / DOI 10.1002/dta.2741
- Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease.Muscle & nerve / 2009 MarPMID 19208403 / DOI 10.1002/mus.21244
- Follistatin Gene Therapy Improves Ambulation in Becker Muscular Dystrophy.Journal of neuromuscular diseases / 2015 Sep 2PMID 27858738 / DOI 10.3233/JND-150083
CLINICALTRIALS.GOV / FOUND RECORDS
- Follistatin Gene Transfer to Patients With Becker Muscular Dystrophy and Sporadic Inclusion Body MyositisCOMPLETED / PHASE1 / Nationwide Children's HospitalNCT01519349 / DIRECT intervention MATCH: Follistatin-344