RM-GHA / Growth-hormone-axis signalling
GHRP-6
Also known as: Growth hormone-releasing peptide 6
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
GHRP-6 is a defined synthetic hexapeptide. It is distinct from GHRP-2, hexarelin and modified analogs even though they share a receptor system and are often grouped together by suppliers.
Evidence position
Human pharmacokinetic and endocrine studies support Grade B. The studies are generally small and short, so the grade should not be read as broad effectiveness.
What the record does not establish
The literature does not authenticate commercially supplied material or establish its identity, purity, quantity or microbiological quality.
Sources
- 01Pharmacokinetic study of GHRP-6 in nine healthy volunteersPubMed
- Shows
- Phase I human pharmacokinetic measurements after controlled intravenous administration
- Does not show
- Nine volunteers, acute study and a defined investigational preparation
- 02GHRP-6 requires endogenous GHRH for maximal GH stimulationPubMed
- Shows
- Controlled human mechanistic endocrine study
- Does not show
- Mechanism study, not long-term outcome or lot evidence
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Ghrp-6
- CID
- 4345065
- Formula
- C46H56N12O6
- Mass
- 873.0
PUBMED / FOUND RECORDS
- N-aminoimidazolidin-2-one peptidomimetics.Organic letters / 2014 Apr 18PMID 24697286 / DOI 10.1021/ol500739k
- Growth hormone releasing hexapeptide-6 (GHRP-6) test in the diagnosis of GH-deficiency.Journal of pediatric endocrinology & metabolism : JPEM / 1996 JunPMID 8887178
- Growth hormone-releasing peptide 6 (GHRP-6) hydrogel for acute kidney injury therapy via metabolic regulation.Journal of nanobiotechnology / 2025 Dec 1PMID 41327290 / DOI 10.1186/s12951-025-03888-9
- [D-Lys3]-GHRP-6 exhibits pro-autophagic effects on skeletal muscle.Molecular and cellular endocrinology / 2015 Feb 5PMID 25450862 / DOI 10.1016/j.mce.2014.09.031
- Growth hormone releasing peptide-6 (GHRP-6) prevents doxorubicin-induced myocardial and extra-myocardial damages by activating prosurvival mechanisms.Frontiers in pharmacology / 2024PMID 38873418 / DOI 10.3389/fphar.2024.1402138