RM-GHA / Growth-hormone-axis signalling
Ipamorelin
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
A selective growth-hormone secretagogue pentapeptide. Human volunteer pharmacology has been published.
Evidence position
Grade B. Human pharmacology is not efficacy data and not product-quality proof. FDA lists injectable ipamorelin acetate among substances with potential significant safety risks.
What the record does not establish
Published research about a molecule is not a test of any particular vial. Identity, purity, strength and microbiological quality are established by lot-level analytical records tied to a matched sample — not by the literature, and not by the presence of an approved comparator.
Where a lot-level record exists it is published on the evidence page and linked from the product. Where it does not exist, the record says so.
Sources
- 01Human volunteer pharmacokinetic and pharmacodynamic studyPubMed
- Shows
- Human pharmacology
- Does not show
- Not efficacy; not product quality
- 02Bulk drug substances that may present significant safety risksU.S. Food and Drug Administration
- Shows
- Regulator safety position
- Does not show
- Not a quality assessment of any vial
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Ipamorelin
- CID
- 9831659
- Formula
- C38H49N9O5
- Mass
- 711.9
PUBMED / FOUND RECORDS
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews / 2026 Jan 1PMID 41490200 / DOI 10.5435/JAAOSGlobal-D-25-00236
- Ipamorelin, the first selective growth hormone secretagogue.European journal of endocrinology / 1998 NovPMID 9849822 / DOI 10.1530/eje.0.1390552
- Injectable Peptide Therapy: A Primer for Orthopaedic and Sports Medicine Physicians.The American journal of sports medicine / 2026 JanPMID 41476424 / DOI 10.1177/03635465251357593
- Safety and Efficacy of Approved and Unapproved Peptide Therapies for Musculoskeletal Injuries and Athletic Performance.Sports medicine (Auckland, N.Z.) / 2026 Apr 12PMID 41966639 / DOI 10.1007/s40279-026-02437-0
- Beyond the androgen receptor: the role of growth hormone secretagogues in the modern management of body composition in hypogonadal males.Translational andrology and urology / 2020 MarPMID 32257855 / DOI 10.21037/tau.2019.11.30
CLINICALTRIALS.GOV / FOUND RECORDS
- Safety and Efficacy of Ipamorelin for Management of Post-Operative IleusCOMPLETED / PHASE2 / Helsinn Therapeutics (U.S.), IncNCT00672074 / DIRECT intervention MATCH: Ipamorelin
- Safety and Efficacy of Ipamorelin Compared to Placebo for the Recovery of Gastrointestinal FunctionCOMPLETED / PHASE2 / Helsinn Therapeutics (U.S.), IncNCT01280344 / DIRECT intervention MATCH: Ipamorelin