RM-TRS / Tissue, repair and matrix signalling
Palmitoyl Pentapeptide-4
Also known as: Matrixyl · Palmitoyl Pentapeptide-3 · Pal-KTTKS
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Palmitoyl pentapeptide-4 is Pal-KTTKS. “Matrixyl” is a trade name that can also appear on multi-ingredient systems, so the exact INCI name and composition must accompany the brand term.
Evidence position
A small double-blind human cream study supports Grade B, with supporting laboratory work on related KTTKS analogs. The evidence remains product- and formulation-specific.
What the record does not establish
The study does not establish the identity or activity of every Matrixyl-labelled blend, raw powder or supplier lot. Palmitoylation, sequence, concentration and vehicle cannot be assumed.
Sources
- 01Palmitoyl Pentapeptide-4 compound recordPubChem
- Shows
- Registry identity, sequence, formula and synonyms for Pal-KTTKS
- Does not show
- Chemical identity does not establish performance or lot quality
- 02Randomised trial of palmitoyl pentapeptide-4 creamPubMed
- Shows
- Double-blind human comparison of topical palmitoyl pentapeptide-4, acetylhexapeptide-3 and placebo creams
- Does not show
- One topical formulation study with limited size and duration
- 03KTTKS analog cytotoxicity and proteolytic-activity studyPubMed
- Shows
- Direct in-vitro comparison of KTTKS-derived peptides
- Does not show
- Laboratory endpoints; not a human outcome study
- 04Safety assessment of defined tripeptide and pentapeptide cosmetic ingredientsCosmetic Ingredient Review
- Shows
- Independent ingredient-safety review and identity-grouping discussion
- Does not show
- Safety assessment for cosmetic-use conditions, not evidence of efficacy or supplier approval
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Palmitoyl Pentapeptide-4
- CID
- 9897237
- Formula
- C39H75N7O10
- Mass
- 802.1
PUBMED / FOUND RECORDS
- Bioactive Glycyrrhizic Acid Ionic Liquid Self-Assembled Nanomicelles for Enhanced Transdermal Delivery of Anti-Photoaging Signal Peptides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) / 2025 FebPMID 39783908 / DOI 10.1002/advs.202412581
- Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet.The Journal of clinical and aesthetic dermatology / 2023 FebPMID 36909866
- Synergistic Effects of Injectable Platelet-Rich Fibrin and Bioactive Peptides on Dermal Fibroblast Viability and Extracellular Matrix Gene Expression: An In Vitro Study.Molecules (Basel, Switzerland) / 2025 Aug 19PMID 40871567 / DOI 10.3390/molecules30163415
- Dually functionalized dendrimer for stimuli-responsive release of active ingredients into the skin.Acta biomaterialia / 2025 Jan 24PMID 39694719 / DOI 10.1016/j.actbio.2024.12.035
- The Effects of a Novel Series of KTTKS Analogues on Cytotoxicity and Proteolytic Activity.Molecules (Basel, Switzerland) / 2019 Oct 15PMID 31618846 / DOI 10.3390/molecules24203698