RM-TRS / Tissue, repair and matrix signalling
Acetyl Hexapeptide-8
Also known as: Argireline · Acetyl Hexapeptide-3 · AH8
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Argireline is commonly described as acetyl hexapeptide-8 and historically as acetyl hexapeptide-3. The N-terminal acetyl group, C-terminal acid or amide, counterion and formulation are all part of a reproducible record.
Evidence position
Human topical studies support Grade B, but they are small, narrow or use combination delivery systems. The grade says human intervention data exists; it does not say every marketed form is equivalent.
What the record does not establish
One topical cream or microneedle patch does not qualify an unrelated powder, terminal form or concentration. Published formulation results are not a certificate of identity, purity or performance for a supplier lot.
Sources
- 01Acetyl Hexapeptide-8 acid compound recordPubChem
- Shows
- Registry structure for the free C-terminal acid
- Does not show
- A separate amidated/acetate-associated form is also indexed; the name alone is not a complete identity
- 02Topical acetyl hexapeptide-8 pilot studyPubMed
- Shows
- Randomised placebo-controlled topical pilot study in a narrow clinical context
- Does not show
- Small adjunctive study; does not establish broad cosmetic or therapeutic outcomes
- 03Microneedle patch with acetyl hexapeptide-8 and EGFPubMed
- Shows
- Human split-face formulation study
- Does not show
- Combination product and delivery system; the peptide's independent contribution cannot be isolated
- 04Acetylhexapeptide-8 and sebaceous functionPubMed
- Shows
- Laboratory work plus a randomised split-face topical study
- Does not show
- Narrow endpoint and formulation-specific findings
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Acetyle Hexapeptide-8
- CID
- 91977122
- Formula
- C36H64N14O14S
- Mass
- 949.0
PUBMED / FOUND RECORDS
- Acetyl Hexapeptide-8 in Cosmeceuticals-A Review of Skin Permeability and Efficacy.International journal of molecular sciences / 2025 Jun 14PMID 40565185 / DOI 10.3390/ijms26125722
- Public Interest in Acetyl Hexapeptide-8: Longitudinal Analysis.JMIR dermatology / 2024 Feb 20PMID 38376906 / DOI 10.2196/54217
- Safety Assessment of Acetyl Hexapeptide-8 Amide as Used in Cosmetics.International journal of toxicology / 2025 AugPMID 40673537 / DOI 10.1177/10915818251340391
- The effect of synthetic acetylhexapeptide-8 (AH8) on sebaceous function.International journal of cosmetic science / 2022 AugPMID 35690997 / DOI 10.1111/ics.12795
- Double-blind, Randomized Trial on the Effectiveness of Acetylhexapeptide-3 Cream and Palmitoyl Pentapeptide-4 Cream for Crow's Feet.The Journal of clinical and aesthetic dermatology / 2023 FebPMID 36909866
CLINICALTRIALS.GOV / FOUND RECORDS
- A Study of Acetyl Hexapeptide-8 (AH8) in Treatment of BlepharospasmCOMPLETED / PHASE1, PHASE2 / National Institute of Neurological Disorders and Stroke (NINDS)NCT00942851 / DIRECT title MATCH: Acetyl Hexapeptide-8
- Topical Acetyl Hexapeptide-8 and the Cosmetic Appearance of Oily SkinCOMPLETED / NA / University of California, DavisNCT02597777 / DIRECT intervention MATCH: Acetyl Hexapeptide-8
- Acetyl Hexapeptide-8 for BlepharospasmTERMINATED / PHASE2 / National Institute of Neurological Disorders and Stroke (NINDS)NCT01750346 / DIRECT intervention MATCH: Acetyl Hexapeptide-8