RM-NBS / Neurobehavioural and neuroendocrine signalling
Cortagen
Also known as: AEDP peptide · Ala-Glu-Asp-Pro
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Cortagen is described as Ala-Glu-Asp-Pro in the primary literature. It is a defined synthetic tetrapeptide, not the multi-peptide Cortexin preparation.
Evidence position
Direct animal and mechanistic studies support Grade C. The accessible indexed record does not support promotion to a human-evidence grade.
What the record does not establish
Gene-expression or oxidative-process findings do not establish clinical benefit, an approved formulation or commercial-sample quality.
Sources
- 01Cortagen and gene expression in mouse heartPubMed
- Shows
- Defines Cortagen as Ala-Glu-Asp-Pro and reports microarray findings in mice
- Does not show
- Animal gene-expression study; a statement about prior human use is not a controlled outcome record
- 02Cortagen in chronic cerebral ischemiaPubMed
- Shows
- Direct animal-model research comparing Cortexin and Cortagen
- Does not show
- Preclinical model and narrow research stream
- 03Free-radical effects of bioactive tetrapeptidesPubMed
- Shows
- Mechanistic comparison including Cortagen
- Does not show
- Laboratory endpoints, not a human outcome study
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBMED / FOUND RECORDS
- Tissue-specific effects of peptides.Bulletin of experimental biology and medicine / 2001 AugPMID 11713572 / DOI 10.1023/a:1013058701974
- Effects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathway.Bulletin of experimental biology and medicine / 2002 MayPMID 12420072 / DOI 10.1023/a:1019830308824
- Effects of bioactive tetrapeptides on free-radical processes.Bulletin of experimental biology and medicine / 2007 JunPMID 18239817 / DOI 10.1007/s10517-007-0230-8
- Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.Neuro endocrinology letters / 2004 Feb-AprPMID 15159690
- EPIGENETIC MODIFICATION UNDER THE INFLUENCE OF PEPTIDE BIOREGULATORS ON THE "OLD" CHROMATIN.Georgian medical news / 2023 FebPMID 37042594