RM-TRS / Tissue, repair and matrix signalling
Bronchogen
Also known as: AEDL peptide · Ala-Glu-Asp-Leu
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Bronchogen is described in the cited primary literature as the tetrapeptide Ala-Glu-Asp-Leu. A catalog label without that sequence is not a complete identity.
Evidence position
Direct cell and animal work supports Grade C. The indexed record is concentrated in one research stream and does not include a qualifying human intervention study.
What the record does not establish
Gene expression in cultured cells and morphology in a rat model do not establish a clinical outcome, route, dose or commercial-lot quality.
Sources
- 01Tissue-specific stimulation of cell differentiation by short peptidesPubMed
- Shows
- Defines bronchogen as Ala-Glu-Asp-Leu and reports gene-expression findings in cultured human bronchial cells
- Does not show
- Cell-culture study from one research group; not a human outcome trial
- 02Bronchogen in a rat model of obstructive lung pathologyPubMed
- Shows
- Direct animal-model findings for bronchial epithelium
- Does not show
- Rat model only; does not establish human outcome or supplier-lot quality
- 03Short-peptide interaction with DNA structuresPubMed
- Shows
- Defines bronchogen as Ala-Glu-Asp-Leu and reports laboratory interaction measurements
- Does not show
- Mechanistic in-vitro evidence only
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBMED / FOUND RECORDS
- Short Exogenous Peptides Regulate Expression of CLE, KNOX1, and GRF Family Genes in Nicotiana tabacum.Biochemistry. Biokhimiia / 2017 AprPMID 28371610 / DOI 10.1134/S0006297917040149
- Peptides tissue-specifically stimulate cell differentiation during their aging.Bulletin of experimental biology and medicine / 2012 MayPMID 22808515 / DOI 10.1007/s10517-012-1664-1
- Effect of the peptide bronchogen (Ala-Asp-Glu-Leu) on DNA thermostability.Bulletin of experimental biology and medicine / 2011 JanPMID 21240358 / DOI 10.1007/s10517-011-1146-x
- Penetration of short fluorescence-labeled peptides into the nucleus in HeLa cells and in vitro specific interaction of the peptides with deoxyribooligonucleotides and DNA.Biochemistry. Biokhimiia / 2011 NovPMID 22117547 / DOI 10.1134/S0006297911110022
- Modulating Effect of Peptide Therapy on the Morphofunctional State of Bronchial Epithelium in Rats with Obstructive Lung Pathology.Bulletin of experimental biology and medicine / 2015 SepPMID 26468022 / DOI 10.1007/s10517-015-3047-x