RM-NBS / Neurobehavioural and neuroendocrine signalling
Pinealon
Also known as: EDR peptide · Glu-Asp-Arg
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Pinealon is the defined tripeptide Glu-Asp-Arg. The EDR abbreviation should be paired with the sequence because short abbreviations can match unrelated biological text.
Evidence position
Direct cell and animal studies support Grade C. The literature is concentrated within a small research network and does not establish broad human outcomes.
What the record does not establish
Mechanistic observations, oxidative-stress models and animal cognitive measures do not establish treatment effects, approved use or the quality of a supplier lot.
Sources
- 01Pinealon increases cell viability under oxidative stressPubMed
- Shows
- Direct cell experiments using Pinealon (Glu-Asp-Arg)
- Does not show
- Cell models only; not a human outcome study
- 02Pinealon in a rat prenatal-hyperhomocysteinemia modelPubMed
- Shows
- Direct animal experiments involving cognitive and neuronal measures
- Does not show
- Specialized rat model; not evidence of human efficacy
- 03Short peptides and serotonin expression in brain-cortex cellsPubMed
- Shows
- Direct cell research on the Glu-Asp-Arg sequence
- Does not show
- Laboratory and modeling evidence only
- 04Cell entry and nucleic-acid interaction of short peptidesPubMed
- Shows
- Direct in-vitro research including Pinealon
- Does not show
- Mechanistic cell study; no clinical outcome
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Glu-Asp-Arg
- CID
- 10273502
- Formula
- C15H26N6O8
- Mass
- 418.40
PUBMED / FOUND RECORDS
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews / 2026 Jan 1PMID 41490200 / DOI 10.5435/JAAOSGlobal-D-25-00236
- [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION].Advances in gerontology = Uspekhi gerontologii / 2015PMID 26390612
- Pinealon protects the rat offspring from prenatal hyperhomocysteinemia.International journal of clinical and experimental medicine / 2012PMID 22567179
- Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes.Rejuvenation research / 2011 OctPMID 21978084 / DOI 10.1089/rej.2011.1172
- [Comparative analysis of different methods of geroprotective].Advances in gerontology = Uspekhi gerontologii / 2016PMID 28539017