RM-MCE / Mitochondrial and cellular-energy research
Epitalon
Also known as: Epithalon · AEDG peptide
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Epitalon is generally defined as the tetrapeptide Ala-Glu-Asp-Gly. Epithalon is a common spelling variant. The exact sequence must be confirmed because similarly named preparations may not be chemically equivalent.
Evidence position
The clearest accessible records are mechanistic and preclinical. That supports Grade C, not a clinical or longevity claim.
What the record does not establish
Cell-culture or animal findings do not establish effects in people and do not authenticate a supplier, formulation or lot.
Sources
- 01Peptide Epitalon activates chromatin at the old agePubMed
- Shows
- Ex-vivo cultured lymphocyte findings associated with chromatin measures
- Does not show
- Not a clinical outcome trial and not evidence about a commercial sample
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Epitalon
- CID
- 219042
- Formula
- C14H22N4O9
- Mass
- 390.35
PUBMED / FOUND RECORDS
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews / 2026 Jan 1PMID 41490200 / DOI 10.5435/JAAOSGlobal-D-25-00236
- Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties.International journal of molecular sciences / 2025 Mar 17PMID 40141333 / DOI 10.3390/ijms26062691
- Peptides and Ageing.Neuro endocrinology letters / 2002PMID 12374906
- Epitalon increases telomere length in human cell lines through telomerase upregulation or ALT activity.Biogerontology / 2025 Sep 4PMID 40908429 / DOI 10.1007/s10522-025-10315-x
- Epitalon protects against post-ovulatory aging-related damage of mouse oocytes in vitro.Aging / 2022 Apr 12PMID 35413689 / DOI 10.18632/aging.204007