RM-MCE / Mitochondrial and cellular-energy research
Humanin
Also known as: HN · Mitochondrial-derived peptide Humanin
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Humanin is a 24-amino-acid mitochondrial-derived peptide. Several analogs appear in research, and their substitutions can materially change activity; an analog paper is not an identity record for native Humanin.
Evidence position
The evidence base is dominated by mechanistic, in-vitro, animal and observational work. This supports a preclinical Grade C position.
What the record does not establish
The literature does not establish clinical effectiveness, dosing, or the identity and quality of any separately sourced material.
Sources
- 01Humanin and Its Pathophysiological Roles in Aging: A Systematic ReviewPubMed
- Shows
- Systematic synthesis of mechanistic, preclinical and observational Humanin research
- Does not show
- Does not establish an approved intervention or validate a supplied synthetic analog
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Humanin
- CID
- 16131438
- Formula
- C119H204N34O32S2
- Mass
- 2687.2
PUBMED / FOUND RECORDS
- Mitochondrial stress and mitokines in aging.Aging cell / 2023 FebPMID 36642986 / DOI 10.1111/acel.13770
- Neuron-derived extracellular vesicles in blood reveal effects of exercise in Alzheimer's disease.Alzheimer's research & therapy / 2023 Sep 20PMID 37730689 / DOI 10.1186/s13195-023-01303-9
- Mitochondria-derived peptide SHLP2 regulates energy homeostasis through the activation of hypothalamic neurons.Nature communications / 2023 Jul 19PMID 37468558 / DOI 10.1038/s41467-023-40082-7
- Humanin: Functional Interfaces with IGF-I.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society / 2016 AugPMID 27082450 / DOI 10.1016/j.ghir.2016.03.005
- Mitochondrial-Derived Peptides Exacerbate Senescence.Rejuvenation research / 2018 AugPMID 30058454 / DOI 10.1089/rej.2018.2114
CLINICALTRIALS.GOV / FOUND RECORDS
- Humanin Isoforms in Cardiac Muscle and Blood Plasma and Major Complications After Cardiac OperationCOMPLETED / NO PHASE / University of TartuNCT03431844 / DIRECT title MATCH: Humanin
- Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal TransplantationRECRUITING / NA / University of GaziantepNCT07678073 / DIRECT title MATCH: Humanin
- Humanin's Value for Early Diagnosis and Short-term Prognosis in Patients With AKI After Heart TransplantationUNKNOWN / NO PHASE / Li zhilianNCT06125249 / DIRECT title MATCH: Humanin
- Clinical Value of Plasma Humanin in Acute Kidney InjuryUNKNOWN / NO PHASE / Guangdong Provincial People's HospitalNCT06105229 / DIRECT title MATCH: Humanin