ML-SYS / 2026.07NON-CLINICAL RESEARCH MATERIALSORIGIN DECLARED BY LOT

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RM-MCE / Mitochondrial and cellular-energy research

MOTS-c

Also known as: Mitochondrial ORF of the 12S rRNA type-c

Preclinical evidence

Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.

What this is

A mitochondrial-derived peptide. Foundational work is preclinical and mechanistic.

Evidence position

Grade C. Preclinical context only. No proven human performance or longevity outcome.

What the record does not establish

Published research about a molecule is not a test of any particular vial. Identity, purity, strength and microbiological quality are established by lot-level analytical records tied to a matched sample — not by the literature, and not by the presence of an approved comparator.

Where a lot-level record exists it is published on the evidence page and linked from the product. Where it does not exist, the record says so.

Sources

External database index

LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE

Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.

PUBMED / FOUND RECORDS

  1. MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation.Frontiers in endocrinology / 2023PMID 36761202 / DOI 10.3389/fendo.2023.1120533
  2. The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance.Cell metabolism / 2015 Mar 3PMID 25738459 / DOI 10.1016/j.cmet.2015.02.009
  3. Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination.Advanced science (Weinheim, Baden-Wurttemberg, Germany) / 2024 NovPMID 39321430 / DOI 10.1002/advs.202405620
  4. The mitochondrial-derived peptide MOTS-c relieves hyperglycemia and insulin resistance in gestational diabetes mellitus.Pharmacological research / 2022 JanPMID 34798268 / DOI 10.1016/j.phrs.2021.105987
  5. MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes.Redox biology / 2025 JulPMID 40403491 / DOI 10.1016/j.redox.2025.103681

CLINICALTRIALS.GOV / FOUND RECORDS

  1. Comparison of the Effects of General Anesthesia and Combined Spinal-Epidural Anesthesia on Ferroptosis, Humanin and MOTS-c Levels in Renal TransplantationRECRUITING / NA / University of GaziantepNCT07678073 / DIRECT title MATCH: MOTS-c
  2. MOTS-c for Improving Insulin Sensitivity in Adults With Prediabetes and Overweight/ObesityRECRUITING / PHASE2 / Hudson BiotechNCT07505745 / DIRECT intervention MATCH: MOTS-c
  3. Platelet Reactivity, B-amyloid, MOTS-c and Mortality of Type II Diabetics With CADUNKNOWN / NO PHASE / University of AthensNCT04027712 / DIRECT title MATCH: MOTS-c

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