RM-MCE / Mitochondrial and cellular-energy research
NAD+
Also known as: Nicotinamide adenine dinucleotide
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
A ubiquitous redox cofactor. Direct intravenous human research is limited in scope.
Evidence position
Grade B, with prominent limitations. The available human work is pharmacokinetic and metabolic, not broad efficacy. No energy, anti-ageing or disease claim is supportable.
What the record does not establish
Published research about a molecule is not a test of any particular vial. Identity, purity, strength and microbiological quality are established by lot-level analytical records tied to a matched sample — not by the literature, and not by the presence of an approved comparator.
Where a lot-level record exists it is published on the evidence page and linked from the product. Where it does not exist, the record says so.
Sources
- 01Six-hour human infusion pilotPubMed
- Shows
- Human pharmacokinetic data
- Does not show
- Small pilot; not efficacy
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Nadide
- CID
- 5892
- Formula
- C21H27N7O14P2
- Mass
- 663.4
PUBMED / FOUND RECORDS
- NAD(+) metabolism and its roles in cellular processes during ageing.Nature reviews. Molecular cell biology / 2021 FebPMID 33353981 / DOI 10.1038/s41580-020-00313-x
- NAD+ and sirtuins in aging and disease.Trends in cell biology / 2014 AugPMID 24786309 / DOI 10.1016/j.tcb.2014.04.002
- NAD(+) homeostasis in health and disease.Nature metabolism / 2020 JanPMID 32694684 / DOI 10.1038/s42255-019-0161-5
- NAD(+) metabolism, stemness, the immune response, and cancer.Signal transduction and targeted therapy / 2021 Jan 1PMID 33384409 / DOI 10.1038/s41392-020-00354-w
- Evolving concepts in NAD(+) metabolism.Cell metabolism / 2021 Jun 1PMID 33930322 / DOI 10.1016/j.cmet.2021.04.003
CLINICALTRIALS.GOV / FOUND RECORDS
- Study of the Fetal and Maternal Microbiota in Preganant Women With Fetal Defect GrowthTERMINATED / NO PHASE / Universidad de GranadaNCT04047966 / DIRECT title MATCH: NAD+
- Absorption and Tolerability of Injectable Administration of Niagen®+, as Compared to NAD+RECRUITING / NA / Nutraceuticals Research InstituteNCT06919328 / DIRECT intervention MATCH: NAD+
- Measurement of NAD+ Synthesis in Human Skeletal MuscleCOMPLETED / NA / AdventHealth Translational Research InstituteNCT04905446 / DIRECT title MATCH: NAD+
- Study of Weekly Paclitaxel, Carboplatin and Irinotecan to Treat Lung CancerTERMINATED / PHASE2 / Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsNCT00465907 / DIRECT title MATCH: NAD+
- NAD Augmentation in Diabetes Kidney DiseaseRECRUITING / PHASE2 / Brigham and Women's HospitalNCT05759468 / DIRECT title MATCH: NAD+