RM-NBS / Neurobehavioural and neuroendocrine signalling
Semax
Also known as: ACTH 4-10 analog
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
A synthetic ACTH fragment analog developed in Russia. Limited clinical literature exists, largely in a single non-English research stream.
Evidence position
Grade B, limited. Not an FDA-approved U.S. drug. A single foreign-language clinical literature stream is not broad proof.
What the record does not establish
Published research about a molecule is not a test of any particular vial. Identity, purity, strength and microbiological quality are established by lot-level analytical records tied to a matched sample — not by the literature, and not by the presence of an approved comparator.
Where a lot-level record exists it is published on the evidence page and linked from the product. Where it does not exist, the record says so.
Sources
- 01Clinical stroke-rehabilitation studyPubMed
- Shows
- Human clinical data
- Does not show
- Narrow literature base; not US-approved
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
ACTH (4-7), Pro-Gly-Pro-
- CID
- 9811102
- Formula
- C37H51N9O10S
- Mass
- 813.9
PUBMED / FOUND RECORDS
- Therapeutic Peptides in Orthopaedics: Applications, Challenges, and Future Directions.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews / 2026 Jan 1PMID 41490200 / DOI 10.5435/JAAOSGlobal-D-25-00236
- Functional Connectomic Approach to Studying Selank and Semax Effects.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections / 2020 JanPMID 32342318 / DOI 10.1134/S001249662001007X
- Semax peptide targets the μ opioid receptor gene Oprm1 to promote deubiquitination and functional recovery after spinal cord injury in female mice.British journal of pharmacology / 2025 NovPMID 40692165 / DOI 10.1111/bph.70122
- Pharmacological Aspects of Neuro-Immune Interactions.Current pharmaceutical design / 2018PMID 28875850 / DOI 10.2174/1381612823666170829135115
- ACTH-like Peptides Compensate Rat Brain Gene Expression Profile Disrupted by Ischemia a Day After Experimental Stroke.Biomedicines / 2024 Dec 13PMID 39767736 / DOI 10.3390/biomedicines12122830