RM-TRS / Tissue, repair and matrix signalling
PNC-27
Also known as: p53-derived penetratin peptide PNC-27
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
PNC-27 combines a p53-derived HDM2-binding region with a membrane-penetrating sequence. The full chimeric structure is essential to identity.
Evidence position
Cell-culture and other preclinical publications support Grade C. No direct human intervention record was identified.
What the record does not establish
Selective effects in cell models do not establish effects in humans, and the literature does not authenticate an independently manufactured sample.
Sources
- 01PNC-27 induces tumor-cell lysis as the intact peptidePubMed
- Shows
- In-vitro mechanistic research using cancer and non-transformed cell lines
- Does not show
- Cell models only; no human clinical outcome and no supplier-lot validation
- 02PNC-27 chimeric peptide structure and membrane-pore researchPubMed
- Shows
- Review and experimental synthesis of the proposed cellular mechanism
- Does not show
- Does not establish human effectiveness or product quality
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBMED / FOUND RECORDS
- Conjugated PNC-27 peptide/PEI-superparamagnetic iron oxide nanoparticles (SPIONs) as a double targeting agent for early cancer diagnosis: In vitro study.Iranian journal of basic medical sciences / 2022 OctPMID 36311203 / DOI 10.22038/IJBMS.2022.65590.14430
- Ex vivo Efficacy of Anti-Cancer Drug PNC-27 in the Treatment of Patient-Derived Epithelial Ovarian Cancer.Annals of clinical and laboratory science / 2015 FallPMID 26663795
- NMR solution structure of a peptide from the mdm-2 binding domain of the p53 protein that is selectively cytotoxic to cancer cells.Biochemistry / 2004 Feb 24PMID 14967026 / DOI 10.1021/bi035718g