RM-MCE / Mitochondrial and cellular-energy research
FOXO4-DRI
Also known as: FOXO4 D-retro-inverso peptide
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
FOXO4-DRI is a designed D-retro-inverso peptide, not a naturally occurring peptide hormone. Its stereochemistry and full sequence are core parts of identity and cannot be inferred from the name.
Evidence position
The primary record consists of in-vitro and animal work. That supports Grade C and no human outcome claim.
What the record does not establish
Mouse and cell results do not establish human effects, and the literature does not test a supplier’s material or lot.
Sources
- 01Targeted apoptosis of senescent cells restores tissue homeostasisPubMed
- Shows
- Original cell and mouse research describing FOXO4-DRI design and senescent-cell findings
- Does not show
- Preclinical models only; no human clinical outcome or retail-material validation
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Foxo4-dri
- CID
- 167312269
- Formula
- C228H388N86O64
- Mass
- 5358
PUBMED / FOUND RECORDS
- Eliminating Senescent Cells Can Promote Pulmonary Hypertension Development and Progression.Circulation / 2023 Feb 21PMID 36515093 / DOI 10.1161/CIRCULATIONAHA.122.058794
- The disordered p53 transactivation domain is the target of FOXO4 and the senolytic compound FOXO4-DRI.Nature communications / 2025 Jul 1PMID 40593617 / DOI 10.1038/s41467-025-60844-9
- FOXO4-DRI regulates endothelial cell senescence via the P53 signaling pathway.Frontiers in bioengineering and biotechnology / 2025PMID 41625068 / DOI 10.3389/fbioe.2025.1729166
- FOXO4-DRI induces keloid senescent fibroblast apoptosis by promoting nuclear exclusion of upregulated p53-serine 15 phosphorylation.Communications biology / 2025 Feb 24PMID 39994346 / DOI 10.1038/s42003-025-07738-0
- FOXO4-DRI improves spermatogenesis in aged mice through reducing senescence-associated secretory phenotype secretion from Leydig cells.Experimental gerontology / 2024 Oct 1PMID 39025385 / DOI 10.1016/j.exger.2024.112522