RM-TRS / Tissue, repair and matrix signalling
PNC-28
Also known as: Short PNC peptide analog
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
PNC-28 is a shorter analog in the PNC peptide family. It is not interchangeable with PNC-27, even when supplier descriptions group them together.
Evidence position
The direct record is limited and much of the accessible literature concerns PNC-27. That boundary supports Grade D.
What the record does not establish
Related-peptide research does not establish the identity, performance or quality of PNC-28 material.
Sources
- 01Poptosis or peptide-induced transmembrane pore formationPubMed
- Shows
- Review discussing PNC-27 and its shorter PNC-28 analog
- Does not show
- Review and related-compound evidence; not a direct human or lot-quality record
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBMED / FOUND RECORDS
- PNC-28, a p53-derived peptide that is cytotoxic to cancer cells, blocks pancreatic cancer cell growth in vivo.International journal of cancer / 2006 Oct 1PMID 16688716 / DOI 10.1002/ijc.22029
- The penetratin sequence in the anticancer PNC-28 peptide causes tumor cell necrosis rather than apoptosis of human pancreatic cancer cells.Annals of surgical oncology / 2008 DecPMID 18931881 / DOI 10.1245/s10434-008-0147-0
- PNC-27, a Chimeric p53-Penetratin Peptide Binds to HDM-2 in a p53 Peptide-like Structure, Induces Selective Membrane-Pore Formation and Leads to Cancer Cell Lysis.Biomedicines / 2022 Apr 20PMID 35625682 / DOI 10.3390/biomedicines10050945
- The role of ETFS amino acids on the stability and inhibition of p53-MDM2 complex of anticancer p53-derivatives peptides: Density functional theory and molecular docking studies.Journal of molecular graphics & modelling / 2023 JulPMID 37086514 / DOI 10.1016/j.jmgm.2023.108472
- Poptosis or Peptide-Induced Transmembrane Pore Formation: A Novel Way to Kill Cancer Cells without Affecting Normal Cells.Biomedicines / 2024 May 22PMID 38927351 / DOI 10.3390/biomedicines12061144