RM-TRS / Tissue, repair and matrix signalling
Pentapeptide-18
Also known as: Leuphasyl · YAGFL peptide
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Pentapeptide-18 is a defined five-residue cosmetic peptide. Trade-name percentages may describe a supplier solution rather than the active peptide concentration.
Evidence position
Direct formulation and laboratory research supports Grade C. The human evidence base is too small and commercially entangled to imply a broad outcome.
What the record does not establish
The record does not validate a raw supplier lot, an injection route or equivalence across finished formulations.
Sources
- 01Pentapeptide-18 compound recordPubChem
- Shows
- Registry identity and molecular properties
- Does not show
- Registry identity does not establish topical performance
- 02Retinol and Pentapeptide-18 nanoparticle studyPubMed
- Shows
- Direct formulation and characterization research involving Pentapeptide-18
- Does not show
- Combination with retinol and a delivery system; not a peptide-only human outcome
- 03Pentapeptide-18 market listingCore Peptides
- Shows
- Current research-market use of the Pentapeptide-18 and Leuphasyl names
- Does not show
- Supplier copy is not independent clinical evidence or lot verification
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Pentapeptide-18
- CID
- 10099522
- Formula
- C29H39N5O7
- Mass
- 569.6
PUBMED / FOUND RECORDS
- Solid Lipid Nanoparticles Incorporated with Retinol and Pentapeptide-18-Optimization, Characterization, and Cosmetic Application.International journal of molecular sciences / 2024 Sep 19PMID 39337562 / DOI 10.3390/ijms251810078
- Pentapeptide-18 as an anti-aging candidate: Spectroscopic characterization and molecular interaction analysis.Computational biology and chemistry / 2026 AugPMID 41722287 / DOI 10.1016/j.compbiolchem.2026.108952
- D-tyrosine adds an anti-melanogenic effect to cosmetic peptides.Scientific reports / 2020 Jan 14PMID 31937863 / DOI 10.1038/s41598-019-57159-3
- In Vitro and In Silico Assessment of Anticancer Activity of Venom-Derived and Biomimetic Neurotransmitter Inhibitor Pentapeptides.Cell biochemistry and biophysics / 2026 Jul 7PMID 42412310 / DOI 10.1007/s12013-026-02095-z
- Retinol and Oligopeptide-Loaded Lipid Nanocarriers as Effective Raw Material in Anti-Acne and Anti-Aging Therapies.Life (Basel, Switzerland) / 2024 Sep 24PMID 39459512 / DOI 10.3390/life14101212