RM-NBS / Neurobehavioural and neuroendocrine signalling
Orexin A
Also known as: Hypocretin-1 · Orexin-A
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Orexin A is one of two endogenous orexin neuropeptides. It is distinct from orexin B, receptor antagonists and small-molecule receptor agonists that dominate parts of the clinical literature.
Evidence position
A small direct human administration study supports Grade B, with a narrow evidence boundary.
What the record does not establish
Research on orexin receptors or non-peptide drugs cannot be used as direct evidence for an Orexin A sample. Published work does not authenticate a commercial vial.
Sources
- 01Intranasal orexin A modulates sympathetic vascular tone: pilot studyPubMed
- Shows
- Double-blind crossover administration study in ten healthy men
- Does not show
- Small acute pilot; does not establish long-term safety, effectiveness or supplier quality
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Orexin A
- CID
- 56842143
- Formula
- C152H243N47O44S4
- Mass
- 3561.1
PUBMED / FOUND RECORDS
- Bidirectional gut-brain communication: A role for orexin-A.Neurochemistry international / 2020 DecPMID 33068686 / DOI 10.1016/j.neuint.2020.104882
- Therapeutic effects of orexin-A in sepsis-associated encephalopathy in mice.Journal of neuroinflammation / 2024 May 17PMID 38760784 / DOI 10.1186/s12974-024-03111-w
- Plasma Orexin-A Levels in Patients With Schizophrenia: A Systematic Review and Meta-Analysis.Frontiers in psychiatry / 2022PMID 35693955 / DOI 10.3389/fpsyt.2022.879414
- Orexin-A in Patients With Lewy Body Disease: A Systematic Review and Meta-Analysis.Frontiers in endocrinology / 2021PMID 34867809 / DOI 10.3389/fendo.2021.765701
- Orexin-A and Circadian Disruption in Alzheimer's Disease: Implications for Amyloid-Beta Pathology.Molecular neurobiology / 2025 Dec 3PMID 41335394 / DOI 10.1007/s12035-025-05456-6
CLINICALTRIALS.GOV / FOUND RECORDS
- The Value of Combined Detection of Orexin-A, HLA Gene, PSG and MSLT in the Evaluation of Patients With NarcolepsyUNKNOWN / NO PHASE / Qianfoshan HospitalNCT04940806 / DIRECT title MATCH: Orexin A