RM-END / Endocrine and peptide-hormone analogs
Nafarelin
Also known as: Synarel · Nafarelin acetate · RS-94991
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Nafarelin is a synthetic decapeptide GnRH agonist. The labeled comparator is a metered nasal acetate solution, not a generic peptide vial.
Evidence position
The regulated nasal product and human evidence support Grade A for the named presentation.
What the record does not establish
The product record does not authenticate a separate powder or establish another route or formulation.
Sources
- 01Nafarelin compound recordPubChem
- Shows
- Registry identity, structure, formula and synonyms for nafarelin
- Does not show
- Does not establish the acetate nasal formulation or another material's quality
- 02Synarel prescribing informationDailyMed / U.S. National Library of Medicine
- Shows
- Current U.S. label, decapeptide identity, route and metered presentation
- Does not show
- Does not qualify a different route, container, concentration or source
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Nafarelin
- CID
- 25077405
- Formula
- C66H83N17O13
- Mass
- 1322.5
PUBMED / FOUND RECORDS
- Hereditary Coproporphyria. / 1993PMID 23236641
- Endometriosis: treatment strategies.Annals of the New York Academy of Sciences / 2003 NovPMID 14644830 / DOI 10.1196/annals.1290.026
- Transdermal iontophoresis.Expert opinion on drug delivery / 2006 JanPMID 16370945 / DOI 10.1517/17425247.3.1.127
- An overview of treatments for endometriosis.JAMA / 2015 Jan 20PMID 25603001 / DOI 10.1001/jama.2014.17119
- Uses of GnRH agonists.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN / 1994 SepPMID 7996307 / DOI 10.1111/j.1552-6909.1994.tb01922.x
CLINICALTRIALS.GOV / FOUND RECORDS
- Natural Versus HRT Cycles in Frozen Embryo Replacement TreatmentCOMPLETED / PHASE4 / University of OxfordNCT00843570 / DIRECT intervention MATCH: Nafarelin
- Comparison of Pregnancy Rates in Modified Natural Frozen Embryo Transfer (FET) Cycle After Luteal Support with GnRH Agonist Versus ProgesteroneNOT_YET_RECRUITING / EARLY_PHASE1 / Shaare Zedek Medical CenterNCT06870266 / DIRECT intervention MATCH: Nafarelin
- Injection Free IVFWITHDRAWN / PHASE2 / Insel Gruppe AG, University Hospital BernNCT04850261 / DIRECT intervention MATCH: Nafarelin
- Luteal Phase Support With GnRH Agonist After GnRH Agonist Triggering in IVF/ICSI CyclesRECRUITING / PHASE3 / Assistance Publique - Hôpitaux de ParisNCT06150703 / DIRECT intervention MATCH: Nafarelin
- Intranasal Nafarelin For Triggering Oocyte MaturationNOT_YET_RECRUITING / PHASE4 / Fundacion DexeusNCT06763926 / DIRECT intervention MATCH: Nafarelin