RM-END / Endocrine and peptide-hormone analogs
Triptorelin
Also known as: Triptorelin pamoate · Trelstar
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Triptorelin is a synthetic GnRH agonist. The labeled comparators are depot formulations with defined release intervals.
Evidence position
The regulated product record supports Grade A for the labeled depot presentations.
What the record does not establish
Clinical and label records for a depot do not transfer to a separately sourced peptide or different formulation.
Sources
- 01Trelstar prescribing informationDailyMed / U.S. National Library of Medicine
- Shows
- U.S. label for defined triptorelin pamoate depot presentations
- Does not show
- Does not qualify another salt, strength, release system or source
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Triptorelin
- CID
- 25074470
- Formula
- C64H82N18O13
- Mass
- 1311.4
PUBMED / FOUND RECORDS
- Triptorelin. / 2012PMID 31644065
- Triptorelin for the treatment of endometriosis.Expert opinion on pharmacotherapy / 2014 JunPMID 24832495 / DOI 10.1517/14656566.2014.916279
- Gonadotropin Releasing Hormone (GnRH) Analogues. / 2012PMID 31643199
- An overview of treatments for endometriosis.JAMA / 2015 Jan 20PMID 25603001 / DOI 10.1001/jama.2014.17119
- Triptorelin embonate (6-month formulation).Drugs / 2010 Feb 12PMID 20166771 / DOI 10.2165/11202230-000000000-00000
CLINICALTRIALS.GOV / FOUND RECORDS
- Effects of Triptorelin Pamoate in Children With Precocious Puberty - Follow up StudyCOMPLETED / PHASE3 / IpsenNCT00909844 / DIRECT intervention MATCH: Triptorelin
- The Effect of Pre-treatment With GnRH Analogues Prior in Vitro Fertilization in Patients With EndometriosisCOMPLETED / PHASE4 / Instituto de Investigacion Sanitaria La FeNCT01581359 / DIRECT intervention MATCH: Triptorelin
- Androgen Deprivation Therapy or Androgen Deprivation Therapy Plus Definitive Treatment (Radiation or Surgery)UNKNOWN / PHASE2 / Fudan UniversityNCT02742675 / DIRECT intervention MATCH: Triptorelin
- Treatment of Poor Ovarian Responders With Corifollitropin Alfa Followed by hpHMG in a Short GnRH Agonist ProtocolCOMPLETED / PHASE2 / Universitair Ziekenhuis BrusselNCT01732068 / DIRECT intervention MATCH: Triptorelin
- Hormone Therapy and Combination Chemotherapy Before and After Surgery in Treating Patients With Stage I-IIIA Breast CancerTERMINATED / PHASE2 / University of WashingtonNCT00194792 / DIRECT intervention MATCH: Triptorelin