RM-MET / Metabolic and incretin signalling
HGH Fragment 176-191
Also known as: hGH 176-191 ยท Somatotropin fragment 176-191
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
HGH Fragment 176-191 reproduces the final 16 residues of human growth hormone. AOD-9604 is a different 16-residue analog: it uses tyrosine followed by hGH residues 177-191.
Evidence position
The exact fragment has a small direct laboratory record. Grade C does not borrow the larger preclinical or human-development record attached to AOD-9604.
What the record does not establish
A shared 15-residue core does not make the two compounds interchangeable. Sequence, disulfide state, salt form and lot-level analytical results must match the named material.
Sources
- 01HGH Fragment 176-191 compound recordPubChem
- Shows
- Chemical registry record for the HGH 176-191 material
- Does not show
- An identity record does not establish biological effects or a supplier lot
- 02HGH Fragment 176-191 with doxorubicin nanoparticles in breast-cancer cellsPubMed
- Shows
- Direct in-vitro experiment using HGH Fragment 176-191
- Does not show
- Cell and nanoparticle study; no human outcome evidence
- 03AOD9604 detection and in-vitro metabolismPubMed
- Shows
- Defines AOD-9604 as hGH 177-191 with an added N-terminal tyrosine
- Does not show
- Identity comparison only; AOD-9604 evidence is not fragment 176-191 evidence
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
HGH Fragment 176-191
- CID
- 172966176
- Formula
- C80H127N23O24S2
- Mass
- 1859.1
PUBMED / FOUND RECORDS
- Human Growth Hormone Fragment 176-191 Peptide Enhances the Toxicity of Doxorubicin-Loaded Chitosan Nanoparticles Against MCF-7 Breast Cancer Cells.Drug design, development and therapy / 2022PMID 35783198 / DOI 10.2147/DDDT.S367586