RM-TRS / Tissue, repair and matrix signalling
Cardiogen
Also known as: AEDR peptide · Ala-Glu-Asp-Arg
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Cardiogen is identified in the cited review as the tetrapeptide Ala-Glu-Asp-Arg, or AEDR. It must not be confused with CardioGen-82, a radiopharmaceutical generator that appears in unrelated search results.
Evidence position
Direct chemistry and preclinical records support Grade C. The cardiac evidence is essentially ex-vivo tissue culture from one research group; the in-vivo paper naming Cardiogen uses a tumor endpoint rather than a cardiovascular one.
What the record does not establish
The record does not establish a human cardiac outcome, pharmacokinetics, safety, an approved use or the identity and quality of a supplier lot.
Sources
- 01Peptide regulation of gene expression: systematic reviewPubMed
- Shows
- The originating research group maps Cardiogen to the AEDR sequence and summarizes the short-peptide framework
- Does not show
- Group-authored review; the identity mapping is useful, but it is not independent functional replication
- 02Cardiogen in young and aged rat myocardial tissue culturePubMed
- Shows
- Reports proliferation and p53-expression findings in ex-vivo myocardial tissue culture
- Does not show
- Cultured rat tissue only; not a living-heart disease model or human outcome
- 03AEDR interaction with histones and DNA complexesPubMed
- Shows
- Direct laboratory study including the Ala-Glu-Asp-Arg sequence
- Does not show
- Plant-histone and oligonucleotide assay; does not establish cardiac activity
- 04Cardiogen in an aged-rat sarcoma modelPubMed
- Shows
- An in-vivo animal study that directly names Cardiogen
- Does not show
- Cancer and tumor-vascular endpoints, not cardiac function; cannot support a cardiovascular claim
- 05AEDR chemical identityPubChem
- Shows
- Registry record for H-Ala-Glu-Asp-Arg-OH, formula and molecular weight
- Does not show
- Registry identity does not authenticate a Cardiogen-labelled supplier sample
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
H-Ala-Glu-Asp-Arg-OH
- CID
- 11583989
- Formula
- C18H31N7O9
- Mass
- 489.5
PUBMED / FOUND RECORDS
- Tumor-modifying effect of cardiogen peptide on M-1 sarcoma in senescent rats.Bulletin of experimental biology and medicine / 2009 SepPMID 20396706 / DOI 10.1007/s10517-010-0730-9
- [The effect of the amino acids and cardiogen on the development of myocard tissue culture from young and old rats].Advances in gerontology = Uspekhi gerontologii / 2009PMID 20210190
- [The tissue-specific effect of synthetic peptides-biologic regulators in organotypic tissues culture in young and old rats].Advances in gerontology = Uspekhi gerontologii / 2006PMID 17152728
- [Peptidergic regulation of the expression of signal factors of fibroblast differentiation in the human prostate gland in cell aging].Advances in gerontology = Uspekhi gerontologii / 2010PMID 20586252