ML-SYS / 2026.07NON-CLINICAL RESEARCH MATERIALSORIGIN DECLARED BY LOT

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RM-MCE / Mitochondrial and cellular-energy research

AICAR

Also known as: AICA riboside · Acadesine · AICA ribotide · ZMP

Identity insufficiently defined

Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.

What this is

AICAR is a market acronym with two common chemical meanings. Neither is a peptide. The unphosphorylated nucleoside is acadesine; the intracellular monophosphate is AICA ribotide or ZMP.

Evidence position

The entry remains Grade U because a bare AICAR label does not resolve which structure is present.

What the record does not establish

Research on acadesine cannot authenticate an AICA-ribotide sample, and neither record validates a seller, vial or intended use.

Sources

  • 01
    AICA ribotide compound recordPubChem
    Shows
    Phosphorylated nucleotide identity, formula and synonyms
    Does not show
    This record is not the same structure as acadesine
  • 02
    Acadesine compound recordPubChem
    Shows
    Ribonucleoside identity for acadesine or AICA-riboside
    Does not show
    The name AICAR is used inconsistently across literature and product pages
  • 03
    Systematic review of AICAr pharmacologyPubMed
    Shows
    Distinguishes AICA-riboside use and documents AMPK-independent effects
    Does not show
    Mechanism review; not a peptide record and not supplier-quality evidence

External database index

LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE

Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.

PUBMED / FOUND RECORDS

  1. AICA-riboside (acadesine), an activator of AMP-activated protein kinase with potential for application in hematologic malignancies.Expert opinion on investigational drugs / 2010 AprPMID 20367195 / DOI 10.1517/13543781003703694
  2. CD137L promotes immune surveillance in melanoma via HLTF regulation.Nature communications / 2025 Sep 26PMID 41006211 / DOI 10.1038/s41467-025-63338-w
  3. Negative pressure wound therapy improves bone regeneration by promoting osteogenic differentiation via the AMPK-ULK1-autophagy axis.Autophagy / 2022 SepPMID 34964701 / DOI 10.1080/15548627.2021.2016231
  4. Acadesine (AICA-riboside) improves postischemic cardiac recovery.The Annals of thoracic surgery / 1992 JulPMID 1610261 / DOI 10.1016/0003-4975(92)91148-3
  5. Acadesine (AICA-riboside): disposition and metabolism of an adenosine-regulating agent.Journal of clinical pharmacology / 1993 OctPMID 8227467 / DOI 10.1002/j.1552-4604.1993.tb01929.x

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