RM-TRS / Tissue, repair and matrix signalling
Thymosin Beta 4
Also known as: Tbeta4 · Tβ4 · Thymosin beta-4 · TMSB4X peptide
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Thymosin beta 4 is a naturally occurring 43-amino-acid peptide. It must be kept separate from seller uses of the name TB-500.
Evidence position
Defined topical and intravenous preparations have human interventional records, supporting Grade B.
What the record does not establish
Those studies do not validate a fragment, a different formulation or a commercial vial sold under another name.
Sources
- 01Randomized study of topical thymosin beta 4 in venous ulcersPubMed
- Shows
- Human randomized controlled study of a defined topical preparation
- Does not show
- Does not establish another route, fragment, formulation or supplier lot
- 02First-in-human study of recombinant human thymosin beta 4PubMed
- Shows
- Phase I human exposure, pharmacokinetic and tolerability data
- Does not show
- Early phase; does not establish approval or equivalence to TB-500
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Thymosin Beta 4
- CID
- 45382195
- Formula
- C212H350N56O78S
- Mass
- 4963
PUBMED / FOUND RECORDS
- Thymosin beta 4 as an Alzheimer disease intervention target identified using human brain organoids.Stem cell reports / 2025 Sep 9PMID 40816274 / DOI 10.1016/j.stemcr.2025.102601
- beta-Thymosins.Annals of the New York Academy of Sciences / 2007 SepPMID 17468232 / DOI 10.1196/annals.1415.018
- Thymosin β4: a multi-functional regenerative peptide. Basic properties and clinical applications.Expert opinion on biological therapy / 2012 JanPMID 22074294 / DOI 10.1517/14712598.2012.634793
- Thymosin beta 4 interactions.Vitamins and hormones / 2003PMID 12852258 / DOI 10.1016/s0083-6729(03)01008-2
- Cardioprotection by Thymosin Beta 4.Vitamins and hormones / 2016PMID 27450736 / DOI 10.1016/bs.vh.2016.04.004
CLINICALTRIALS.GOV / FOUND RECORDS
- Safety and Efficacy of Thymosin Beta 4 Ophthalmic Solution in Patients With Dry EyeCOMPLETED / PHASE2 / ReGenTree, LLCNCT01387347 / DIRECT intervention MATCH: Thymosin Beta 4
- Safety and Efficacy Study of Thymosin Beta 4 in Patients With Acute Myocardial Infarction.InfarctionCOMPLETED / PHASE2 / Beijing Northland Biotech. Co., Ltd.NCT05485818 / DIRECT title MATCH: Thymosin Beta 4
- Study of Thymosin Beta 4 in Patients With Venous Stasis UlcersCOMPLETED / PHASE2 / RegeneRx Biopharmaceuticals, Inc.NCT00832091 / DIRECT intervention MATCH: Thymosin Beta 4
- Recombinant Human Thymosin Beta 4 for Injection(NL005) for Acute Myocardial InfarctionNOT_YET_RECRUITING / PHASE2 / Beijing Northland Biotech. Co., Ltd.NCT07586865 / DIRECT intervention MATCH: Thymosin Beta 4
- A Phase 1a Study of Thymosin Beta 4 in Healthy VolunteersCOMPLETED / PHASE1 / Beijing Northland Biotech. Co., Ltd.NCT04555824 / DIRECT intervention MATCH: Thymosin Beta 4