RM-NBS / Neurobehavioural and neuroendocrine signalling
MIF-1
Also known as: Pro-Leu-Gly-NH2 · Melanostatin · MSH release-inhibiting hormone
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
MIF-1 is the amidated tripeptide Pro-Leu-Gly-NH2. The abbreviation is ambiguous across science, so the sequence must accompany the name in any analytical or literature record.
Evidence position
Human research exists, but much of it is historical and small. Grade B records presence of human data, not modern clinical validation.
What the record does not establish
The literature does not establish current approval, a general clinical effect or the identity and quality of a separately supplied sample.
Sources
- 01Improvement in major depression after low subcutaneous doses of MIF-1PubMed
- Shows
- Small human clinical research reported in 1994
- Does not show
- Old, limited study; does not establish current approval, reproducibility or product quality
- 02Brain activation by peptide Pro-Leu-Gly-NH2 (MIF-1)PubMed
- Shows
- Human neuroimaging and mechanistic research on MIF-1
- Does not show
- Mechanistic signal, not a validated clinical outcome
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBMED / FOUND RECORDS
- MIF-1 (Pro-Leu-Gly-NH2) decreases activity in Siamese fighting fish (Betta splendens).Pharmacology, biochemistry, and behavior / 1984 AprPMID 6145165 / DOI 10.1016/0091-3057(84)90314-9
- Endogenous peptide Tyr-Pro-Trp-Gly-NH2 (Tyr-W-MIF-1) is transported from the brain to the blood by peptide transport system-1.Journal of neuroscience research / 1993 Aug 15PMID 8105102 / DOI 10.1002/jnr.490350611
- Isolation of a novel peptide with a unique binding profile from human brain cortex: Tyr-K-MIF-1 (Tyr-Pro-Lys-Gly-NH2).Peptides / 1994PMID 7991457 / DOI 10.1016/0196-9781(94)90056-6
- MIF-1 and Tyr-MIF-1 fail to alter benzodiazepine-induced hypothermia.Pharmacology, biochemistry, and behavior / 1989 MayPMID 2571169 / DOI 10.1016/0091-3057(89)90460-7
- Radioimmunoassay of MIF-1/Tyr-MIF-1-like material in rat pineal.Pharmacology, biochemistry, and behavior / 1980 DecPMID 6111086 / DOI 10.1016/0091-3057(80)90226-9