RM-TRS / Tissue, repair and matrix signalling
Decapeptide-12
Also known as: Lumixyl peptide · YRSRKYSSWY
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Decapeptide-12 is a defined ten-residue synthetic cosmetic peptide. Published human studies evaluated finished topical systems rather than raw peptide powder.
Evidence position
Small human intervention studies support Grade B. Combination products and open-label designs sharply limit attribution.
What the record does not establish
The literature does not establish equivalence across vehicles, concentrations, terminal forms or supplier lots.
Sources
- 01Decapeptide-12 compound recordPubChem
- Shows
- Registry identity, sequence and molecular properties
- Does not show
- Chemical identity does not establish topical performance or lot quality
- 02Open-label multicenter melasma studyPubMed
- Shows
- Human topical study of a system containing 0.01% decapeptide-12
- Does not show
- Open-label combination regimen including cleanser, glycolic acid and sunscreen
- 03Open-label photodamage studyPubMed
- Shows
- Small prospective study of a decapeptide-12-containing skin-care system
- Does not show
- No peptide-only arm and a small sample
- 04Decapeptide-12 market listingCore Peptides
- Shows
- Current research-market use of the ingredient name
- Does not show
- Supplier copy is not independent evidence or lot verification
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Decapeptide-12
- CID
- 25087629
- Formula
- C65H90N18O17
- Mass
- 1395.5
PUBMED / FOUND RECORDS
- Open-label evaluation of the skin-brightening efficacy of a skin-brightening system using decapeptide-12.Journal of cosmetic and laser therapy : official publication of the European Society for Laser Dermatology / 2012 AprPMID 22401652 / DOI 10.3109/14764172.2012.672745
- Combined topical delivery and dermalinfusion of decapeptide-12 accelerates resolution of post-inflammatory hyperpigmentation in skin of color.Journal of drugs in dermatology : JDD / 2014 JanPMID 24385124
- Open-label evaluation of a novel skin brightening system containing 0.01% decapeptide-12 in combination with 20% buffered glycolic acid for the treatment of mild to moderate facial melasma.Journal of drugs in dermatology : JDD / 2013 Jun 1PMID 23839199
- Enhanced skin retention and permeation of a novel peptide via structural modification, chemical enhancement, and microneedles.International journal of pharmaceutics / 2021 Sep 5PMID 34242628 / DOI 10.1016/j.ijpharm.2021.120868