RM-MET / Metabolic and incretin signalling
Adipotide
Also known as: FTPP · Prohibitin-targeting peptidomimetic · CKGGRAKDC-GG-D(KLAKLAK)2
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Adipotide is a composite peptidomimetic that couples a vascular-homing motif to a pro-apoptotic sequence. Exact sequence, D-amino-acid notation and conjugate integrity are part of its identity.
Evidence position
The frequently cited record is a controlled non-human-primate study. It supports a preclinical grade, not a human-evidence grade.
What the record does not establish
Animal weight or insulin findings do not establish human effectiveness, a safe exposure range, or the identity and purity of a separately sourced sample.
Sources
- 01Adipotide study in obese monkeysPubMed
- Shows
- Non-human-primate study of targeted adipose-vascular apoptosis, body composition and insulin sensitivity
- Does not show
- Animal study with reversible renal proximal-tubule changes; not human evidence or a supplier-lot test
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Adipotide
- CID
- 163360068
- Formula
- C111H206N36O28S2
- Mass
- 2557.2
PUBMED / FOUND RECORDS
- A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys.Science translational medicine / 2011 Nov 9PMID 22072637 / DOI 10.1126/scitranslmed.3002621
- A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication.Journal of controlled release : official journal of the Controlled Release Society / 2013 Oct 28PMID 23871959 / DOI 10.1016/j.jconrel.2013.07.013
- Comment on "a peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys".Science translational medicine / 2012 Apr 25PMID 22539771 / DOI 10.1126/scitranslmed.3003760