Melanotan II

Also known as: MT-II · Melanotan 2 · Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Human evidence

Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.

What this is

Melanotan II is a cyclic alpha-MSH analog investigated in small early human studies.

Evidence position

Human evidence supports Grade B, but the record is limited and there is no FDA-approved Melanotan II product.

What the record does not establish

The studies do not validate internet-sold material, a specific vial, long-term use or any supplier claim.

Sources

01
Pilot phase I evaluation of Melanotan IIPubMed
Shows
Early human exposure data in three volunteers
Does not show
Very small phase I study; not an approval or product-quality record
02
Double-blind crossover study of Melanotan IIPubMed
Shows
Controlled human study of a defined investigational peptide
Does not show
Does not establish long-term safety, approval or equivalence of another sample

External database index

LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE

Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.

PUBCHEM / IDENTITY

melanotan-II

CID: 92432
Formula: C50H69N15O9
Mass: 1024.2

Open identity record ↗

PUBMED / FOUND RECORDS

Melanotan-II reverses memory impairment induced by a short-term HF diet.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie / 2023 SepPMID 37478579 / DOI 10.1016/j.biopha.2023.115129
Melanotan II: a possible cause of renal infarction: review of the literature and case report.CEN case reports / 2020 MayPMID 31953620 / DOI 10.1007/s13730-020-00447-z
Melanotan II User Experience: A Qualitative Study of Online Discussion Forums.Dermatology (Basel, Switzerland) / 2021PMID 34464955 / DOI 10.1159/000514492
CLIPSing Melanotan-II to Discover Multiple Functionally Selective hMCR Agonists.Journal of medicinal chemistry / 2022 Mar 10PMID 35188390 / DOI 10.1021/acs.jmedchem.1c01848
Melanoma associated with the use of melanotan-II.Dermatology (Basel, Switzerland) / 2014PMID 24355990 / DOI 10.1159/000356389

CLINICALTRIALS.GOV / FOUND RECORDS

Melanotan II (MT-II) as an Adjunct to NB-UVB Phototherapy for Repigmentation in Stable Nonsegmental VitiligoRECRUITING / PHASE2 / Hudson BiotechNCT07437560 / DIRECT intervention MATCH: Melanotan II

Related compounds

RM-MCS