RM-NBS / Neurobehavioural and neuroendocrine signalling
Kisspeptin-10
Also known as: KP-10 · Metastin 45-54
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Kisspeptin-10 is the minimal C-terminal fragment of kisspeptin with full receptor activity. It must be distinguished from kisspeptin-54 and synthetic analogs when reading research.
Evidence position
Human pharmacology studies support Grade B. These are controlled endocrine experiments, not proof of broad clinical effectiveness.
What the record does not establish
The literature does not authenticate separately sourced material or establish long-term safety, effectiveness, dosage or suitability.
Sources
- 01Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in menPubMed
- Shows
- Small controlled human pharmacology study measuring endocrine responses
- Does not show
- Acute experimental physiology, not long-term effectiveness or product validation
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Kisspeptin-10
- CID
- 25240297
- Formula
- C63H83N17O14
- Mass
- 1302.4
PUBMED / FOUND RECORDS
- Investigating the detection of the novel doping‐relevant peptide kisspeptin‐10 in urine using liquid chromatography high‐resolution mass spectrometry.Biomedical chromatography : BMC / 2024 SepPMID 38978171 / DOI 10.1002/bmc.5946
- Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.Nature communications / 2024 Feb 12PMID 38346942 / DOI 10.1038/s41467-024-44852-9
- Author Correction: Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src.Nature communications / 2024 Dec 19PMID 39702286 / DOI 10.1038/s41467-024-55352-1
- Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity.Scientific reports / 2023 Nov 15PMID 37968564 / DOI 10.1038/s41598-023-47224-3
- Kisspeptin-10 Ameliorates Obesity-Diabetes with Diverse Effects on Ileal Enteroendocrine Cells and Pancreatic Islet Morphology in High-Fat Fed Female Mice.Biomolecules / 2025 Nov 13PMID 41301510 / DOI 10.3390/biom15111591
CLINICALTRIALS.GOV / FOUND RECORDS
- Evaluation of Kisspeptin Glucose-Stimulated Insulin Secretion With Physiologic Mixed Meal ToleranceWITHDRAWN / PHASE1 / Stephanie B. Seminara, MDNCT04532801 / DIRECT intervention MATCH: Kisspeptin-10
- Evaluation of Kisspeptin Stimulated Insulin Secretion With Hyperglycemic ClampWITHDRAWN / PHASE1 / Massachusetts General HospitalNCT05456854 / DIRECT intervention MATCH: Kisspeptin-10
- Link Between the Sensitivity of Kisspeptin Signalling and Pubertal Onset in Boys.COMPLETED / PHASE3 / Ghulam NabiNCT03286517 / DIRECT intervention MATCH: Kisspeptin-10
- Age-dependent Changes in the Responsiveness of Hypothalamic Pituitary Gonadal Axis in MenCOMPLETED / PHASE3 / Quaid-e-Azam UniversityNCT03315325 / DIRECT intervention MATCH: Kisspeptin-10
- KP-10 and Insulin Secretion in MenCOMPLETED / PHASE3 / Quaid-e-Azam UniversityNCT03771326 / DIRECT intervention MATCH: Kisspeptin-10