RM-CVS / Coagulation and vascular signalling
Bivalirudin
Also known as: Angiomax · Hirulog-1
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Bivalirudin is a synthetic peptide that directly inhibits thrombin.
Evidence position
The regulated injection record supports Grade A for the named finished product.
What the record does not establish
Approval does not transfer manufacturing, sterility, fill or formulation controls to another sample.
Sources
- 01Angiomax RTU prescribing informationDailyMed / U.S. National Library of Medicine
- Shows
- U.S. label for a defined ready-to-use bivalirudin injection
- Does not show
- Does not qualify a different presentation, strength or source
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Bivalirudin
- CID
- 16129704
- Formula
- C98H138N24O33
- Mass
- 2180.3
PUBMED / FOUND RECORDS
- Bivalirudin.Thrombosis and haemostasis / 2008 MayPMID 18449412 / DOI 10.1160/TH07-10-0644
- Bivalirudin. / 2026 JanPMID 32491755
- Prospective Randomized Pilot Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric Extracorporeal Membrane Oxygenation.Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies / 2025 Jan 1PMID 39585174 / DOI 10.1097/PCC.0000000000003642
- Bivalirudin in Extracorporeal Membrane Oxygenation.Journal of cardiovascular pharmacology / 2024 Dec 1PMID 39259286 / DOI 10.1097/FJC.0000000000001633
- Assays to Monitor Bivalirudin.Methods in molecular biology (Clifton, N.J.) / 2023PMID 37204724 / DOI 10.1007/978-1-0716-3175-1_24
CLINICALTRIALS.GOV / FOUND RECORDS
- Study Comparing Bivalirudin Versus Heparin in Neonatal and Pediatric ECMOCOMPLETED / PHASE4 / University of Texas Southwestern Medical CenterNCT03318393 / DIRECT intervention MATCH: Bivalirudin
- Bivalirudin/Prasugrel Versus Abciximab/Clopidogrel in Patients Presenting With STEMIUNKNOWN / PHASE4 / I.R.C.C.S Ospedale Galeazzi-Sant'AmbrogioNCT01158846 / DIRECT intervention MATCH: Bivalirudin
- Antithrombotic Effects of Ticagrelor Versus ClopidogrelCOMPLETED / PHASE4 / Juan J BadimonNCT01642238 / DIRECT intervention MATCH: Bivalirudin
- Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial InfarctionCOMPLETED / PHASE3 / Cardiovascular Research Foundation, New YorkNCT00433966 / DIRECT intervention MATCH: Bivalirudin
- Peri-Procedural Myocardial Infarction, Platelet Reactivity, Thrombin Generation, and Clot Strength: Differential Effects of Eptifibatide + Bivalirudin Versus BivalirudinUNKNOWN / PHASE4 / LifeBridge HealthNCT00370045 / DIRECT intervention MATCH: Bivalirudin