RM-END / Endocrine and peptide-hormone analogs
Abaloparatide
Also known as: PTHrP(1-34) analog · Tymlos
Grade describes the published research on the molecule. It is not a quality score, a safety score, or a release state.
What this is
Abaloparatide is an analog of the first 34 residues of human PTH-related peptide.
Evidence position
The regulated pen presentation supports Grade A for that finished product.
What the record does not establish
Approval does not transfer to a separately sourced powder, solution or vial.
Sources
- 01Tymlos prescribing informationDailyMed / U.S. National Library of Medicine
- Shows
- Current U.S. label for the abaloparatide injection product
- Does not show
- Does not qualify a different form, device, formulation or source
External database index
LIVE DATABASE INDEX / SEPARATE FROM CURATED EVIDENCE
Records below come directly from public scientific databases. They help find relevant material, but do not affect the evidence grade until they are matched to the molecule and added to the curated source list.
PUBCHEM / IDENTITY
Abaloparatide
- CID
- 76943386
- Formula
- C174H300N56O49
- Mass
- 3961
PUBMED / FOUND RECORDS
- The clinician's guide to prevention and treatment of osteoporosis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA / 2022 OctPMID 35478046 / DOI 10.1007/s00198-021-05900-y
- Osteoporosis: A Review.JAMA / 2025 Sep 9PMID 40587168 / DOI 10.1001/jama.2025.6003
- Osteoporosis.Lancet (London, England) / 2019 Jan 26PMID 30696576 / DOI 10.1016/S0140-6736(18)32112-3
- Osteoporosis in Older Adults.The Medical clinics of North America / 2020 SepPMID 32773051 / DOI 10.1016/j.mcna.2020.06.004
- Effectiveness and Safety of Treatments to Prevent Fractures in People With Low Bone Mass or Primary Osteoporosis: A Living Systematic Review and Network Meta-analysis for the American College of Physicians.Annals of internal medicine / 2023 FebPMID 36592455 / DOI 10.7326/M22-0684
CLINICALTRIALS.GOV / FOUND RECORDS
- Abaloparatide and Pelvic Fracture HealingCOMPLETED / PHASE2 / Hospital for Special Surgery, New YorkNCT04249232 / DIRECT intervention MATCH: Abaloparatide
- Early Effects of Abaloparatide on Tissue-Based Indices of Bone Formation and ResorptionCOMPLETED / PHASE3 / Radius Health, Inc.NCT03710889 / DIRECT intervention MATCH: Abaloparatide
- Abaloparatide Added to Ongoing Denosumab vs Continued Denosumab AloneACTIVE_NOT_RECRUITING / PHASE4 / Hospital for Special Surgery, New YorkNCT04467983 / DIRECT intervention MATCH: Abaloparatide
- Efficacy & Safety of Abaloparatide-Solid Microstructured Transdermal System in Postmenopausal Women With OsteoporosisCOMPLETED / PHASE3 / Radius Health, Inc.NCT04064411 / DIRECT intervention MATCH: Abaloparatide
- The Effect of Osteoporotic Medications on Vertebral Bone Quality ScoreENROLLING_BY_INVITATION / PHASE2 / State University of New York at BuffaloNCT07587775 / DIRECT intervention MATCH: Abaloparatide